VEGFA and osteoarthritis: Our present study uncovered that miR-149-5p mimics inhibited the VEGF expression, while miR-149-5p inhibitor upregulated the VEGF expression in RA-FLS, indicating that miR-149-5p acted as an angiogenic suppressor in RA-FLS, and the positive effect of miR-149-5p toward the alleviation of the disease in inflammatory condition was consistent with the previous study (Wang et al., 2020) in the chondrocytes of osteoarthritis.