Exposure of RA-FLS to ATO induced decrement of FOXO1/VEGF mRNA and protein levels, and intriguingly, this decrement could be rescued partially by FOXO1 overexpression (Figures 4B,C), miR-149-5p inhibitor (Figures 4D,E), or circHIPK3 overexpression (Figures 4F,G). This evidence concerns the gene FOXO1 and rheumatoid arthritis.