However, it has also been reported that circHIPK3-miR-637-STAT3 could promote oxaliplatin resistance in colorectal cancer through autophagy (Zhang et al., 2019c), and circHIPK3-miR-215-5p-YY1 had the ability to regulate melanoma cell behaviors (Zhu and Sun, 2020). The gene discussed is STAT3; the disease is colorectal cancer.