In the process of myocardial fibrosis, fibroblasts not only produce the ECM, but also express SRY-box transcription factor 9 (SOX9), which is a main regulator of inflammation and functions to increase leukocyte infiltration and the expression of inflammatory mediators (CXCL13 and IL-6) in myocardial tissue, suggesting SOX9 as a new therapeutic target during myocardial infarction (Scharf et al., 2019). Here, SOX9 is linked to myocardial infarction.