MAPK3 and schizophrenia: In particular, our rationale includes the impact of CBD on KET-induced expression of NMDA and AMPA receptor subunits along with ERK1/2 phosphorylation state, in distinct rat brain regions involved in the pathophysiology of schizophrenia, such as the prefrontal cortex (PFC), nucleus accumbens (NAc), dorsal and ventral hippocampus (DH, VH).