SUV39H1 and acute myeloid leukemia: Similarly, Chaetocin has also been reported to directly inhibit the methyl-transferase for lysine nine tri-methylation on histone H3 (SUV39H1) in acute myeloid leukemia (Lai et al., 2015), but some other studies reported that the inhibition of chaetocin in SU(VAR)three to nine was regulated by the accumulation of ROS induced by chaetocin (Chaib et al., 2012; Dixit et al., 2014; Zhang et al., 2017).