It has been reported that the mRNA expression of CD47 could be regulated by NF-κB pathway in liver cancer cells (Lo et al., 2015) and Wnt/β-catenin in glioma cell (Gowda et al., 2018), which could both be regulated by ROS (Vallée and Lecarpentier, 2018; Capece et al., 2019). This evidence concerns the gene NFKB1 and central nervous system cancer.