Research proves that KLF6 in human cancer mainly by p53 independence means an increased expression of p21 (Lang et al., 2013; D'Astolfo et al., 2008), makes the cell cycle of tumor cells stranded in the G1/S transition, and thus plays a role of inhibition of the proliferation of cancer cells, transfer, etc. In a variety of cancers, such as rectal cancer and liver cancer (Reeves et al., 2004; Watanabe et al., 2008), KLF6 can lead to a decreased protein expression level due to gene deletion or mutation, resulting in the occurrence and development of tumors. This evidence concerns the gene KLF6 and cancer.