According to the network pharmacology analysis, PARP1, TP53, ESR1, HNRNPA1, VCAM1, and AR, which are contained in the hub PPI network of ECC targets, COPD genes, and targets, were considered important targets of ECC; in addition, molecular docking demonstrated that the compounds could bind to these targets, which are involved in the inflammatory response. The gene discussed is ESR1; the disease is chronic obstructive pulmonary disease.