Above all, this systematic review and meta-analysis showed an increased risk of malignancies in individuals with peripheral SpA receiving biologics therapy, particularly for IL-17 inhibitors, and small molecule targeted drugs, a slightly increased risk of malignancy in TNF receptor-Fc fusion protein in axial SpA, and increased risk of tuberculosis in individuals with axial SpA treated with anti-TNFα antibody. The gene discussed is IL17A; the disease is tuberculosis.