RPS6 and hepatocellular carcinoma: Western blotting analysis revealed that CUDC-907 upregulated H3K9ac levels, reduced the expression of p-AKT, p-S6, and p4EBP1 (the targets of the PI3K/AKT/mTOR pathway), and suppressed the expression of c-Myc in HCC cell lines (Figure 5B).