APOE and Alzheimer disease: However, after adjusting for age, sex, and APOE alleles, and Bonferroni correction, compared with the CN group, plasma t-tau, and NfL were significantly increased in the AD group (p < 0.001), whereas other plasma biomarkers, including Aβ42 and Aβ40, showed no significant difference (p = 0.308 and p = 0.062, respectively), Aβ42/Aβ40 showed a decreasing tendency, but the difference was not significant (p = 0.056; Table 1; Figure 1).