MAPT and Alzheimer disease: We compared the logistic regression models using classical biomarkers (e.g., Aβ42, Tau, and pTau) as covariates predicting the cognitive diagnosis (AD = 1 vs. SMC_or_Control = 0), to the same models with the contribution of proNGF as a further covariate: the capacity of Aβ42, Tau, and pTau to predict the cognitive status shows an improvement when proNGF is included as a predictor, as witnessed by the increased AUC (Figure 4).