Coherently with the significantly larger NGF levels in controls (CTR) or SMC group compared with AD subjects (Supplementary Figure 7A), comparing the number of samples where NGF could be reliably detected in AD samples (13/84) and CTR+SMC samples (20/28), we observed a significantly higher proportion in CTR + SMC subjects (Fisher's exact test p-value = 8.21*10–8, odds ratio = 13.6). Here, NGF is linked to Alzheimer disease.