In fact, HDAC6 (histone deacetylase 6, a multidomain cytosolic enzyme with α-tubulin deacetylase activity) is increased in AD (Zhang et al., 2013) and HD (Ferrante et al., 2003), and dysregulation of HDACs also take part in ischemic strokes (Fang et al., 2020). Here, HDAC6 is linked to Huntington disease.