MAPT and Alzheimer disease: Similarly, in a work done with human brain homogenates from VaD and AD patients, Mukaetova-Ladinska’s lab found a tendency for reduced levels of tubulin in the temporal lobe of VaD patients (Li et al., 2014), raising the question of whether changes in tubulin, i.e., posttranslational modifications, could be related to the observed loss of tau and neuronal volume.