BRD4 and dopa-responsive dystonia due to sepiapterin reductase deficiency: In animal models, defective BRD4 was associated with impaired synaptic plasticity and memory formation, likely linking this protein to PTSD-related amnesia, depression, and anxiety, while at the same time indicating that BRD4 inhibitors may be therapeutic for SRD (Bruenig et al., 2017; Wang et al., 2021).