SIGMAR1 and post-traumatic stress disorder: As Sig-1R are downregulated by psychological and cellular stress, agonists at these receptors in combination with ARBs, ACEi or amiloride may offer superior therapeutic efficacy to patients with PTSD and severe SARS-CoV-2 (Spottswood et al., 2017; Hashimoto, 2021; Janiri et al., 2021).