A range of therapeutic approaches for AD-associated proteopathies are therefore in various stages of development, including enzyme inhibitors targeting the production pathway of amyloid-beta (Kumar et al., 2018), gene silencing technologies to limit the expression of pro-aggregatory mutant tau proteins (Miller et al., 2004), kinase inhibitors aimed at preventing the pro-aggregatory hyperphosphorylation of tau, passive and active immunotherapies developed to drive protein clearance, and small molecule inhibitors of protein aggregation. Here, MAPT is linked to proteostasis deficiencies.