MAPT and Alzheimer disease: Protein aggregates in AD also induce cytotoxicity through mitochondrial damage; tau oligomers are believed to induce mitochondrial damage via their detrimental effects on intracellular transport networks (Shafiei et al., 2017), while accumulation of amyloid-beta at the mitochondrial membranes induces mitochondrial damage through mechanisms including aberrant interactions with mitochondrial proteins, generation of reactive oxygen species, and disruption of the electron transport chain (reviewed in detail by Reddy et al., 2010, and Chen and Yan, 2007).