Supplementary Table 2 lists these PWS specific transcripts, their function, and evidence that ties these genes or their function to PWS phenotypes. Analyzing the expression of genes across the PWS/AS critical region in our subjects shows the expected expression changes from control to PWS subtypes (Supplementary Figure 1). Specifically, expression of genes that are maternally imprinted in PWS (MAGEL2, SNRPN, SNURF, NDN, and MRKN3) are absent in our PWS groups, regardless of genetic subtype. Here, SNURF is linked to Prader-Willi syndrome.