miR-298 exhibits further biological relevance through its association with sirtuin-3 (SIRT3) (Li et al., 2019), which impacts mitophagy, reactive oxygen species, and toxic protein accumulation (Zhang et al., 2020), known mechanisms involved in ALS, Alzheimer’s disease, and Parkinson’s disease pathogenesis. This evidence concerns the gene SIRT3 and early-onset autosomal dominant Alzheimer disease.