This is in line with the previously mentioned contention that prion-like transfer of pathogenic cargos, including misfolded and aggregated translation products of mutated SOD1, TAR DNA-binding protein of 43 kDa (TDP-43), fused in sarcoma, or C9orf72, may have important implications for propagating neurodegeneration in ALS (Soria et al., 2017; McAlary et al., 2020). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.