TGFB1 and amyotrophic lateral sclerosis: The TGF-β pathway, discussed above, and pathways associated with neurotransmitter systems (e.g., glutamatergic and GABAergic synapses) are in line with the altered inhibitory/excitatory balance present in ALS (Schutz, 2005; Ramirez-Jarquin and Tapia, 2018; Gunes et al., 2020).