Given the equipotency of the two CB1 antagonists with regard to weight loss and metabolic syndrome-like symptoms in rodent obesity models, the results point to a critical dose range in which TM3887 might be beneficial for indications such as obesity and metabolic disorders with limited risk of fear-promoting effects (Micale et al., 2019). The gene discussed is CNR1; the disease is obesity due to melanocortin 4 receptor deficiency.