Studies have reported a CB2 anti-obesity effect by silencing the activated immune cells in mice adipose tissue (Verty et al., 2015; Notarnicola et al., 2016), as well as a diet enriched with olive oil as responsible for increasing CB2 receptor expression in this tissue (Notarnicola et al., 2016). This evidence concerns the gene CNR2 and obesity due to melanocortin 4 receptor deficiency.