CHRNA7 and Sepsis: Sepsis induces a significant upregulation of γ- or α7nAChRs in the sciatic nerve and causes demyelination and neuromuscular dysfunction [51]; however, the glial cell line-derived neurotrophic factor (GDNF) significantly reduces nerve demyelination, improves neuromuscular dysfunction and patients' prognosis, and reduces the expression of γ- or α7nAChRs [52].