CHRNA7 and Sepsis: Acetylcholine is released and acts on α7nAChRs on innate immune cells (such as monocytes) to prevent the activation of monocytes (Figure 1(a)); at the same time, activation of α7nAChRs inhibits releasing proinflammatory cytokines from the innate immune cells through the negative regulation of TLR4 signals [19, 20]; thereby, the immunity and inflammation were suppressed in sepsis [21, 22].