CHRNA7 and intracranial hemorrhage: Intracerebral injection of the α7nAChR agonist PHA-543613 reduces neuroinflammation by activating the JAK2-STAT3 pathway, thereby lessening the short-term and long-term sequelae after intracranial hemorrhage (ICH), while the α7nAChR antagonist MLA has the opposite effect [55]; Transcutaneous vagus nerve stimulation (VNS) also has the effect of lessening brain damage after stroke which may be related to the upregulation of α7nAChRs on the membrane of immune cells and neurons [56].