GTF2H5 (general transcription factor IIH subunit 5, OMIM#608780) could result in the photosensitive trichothiodystrophy-3 (TTD3) (OMIM#616395) [44–46], a rare autosomal recessive disorder characterized by brittle sulfur-deficient hair, ichthyosis, developmental disabilities, decreased fertility, ocular abnormalities, short stature, and infections [47]. The gene discussed is GTF2H5; the disease is trichothiodystrophy 3, photosensitive.