LMNA and laminopathy: Our results bring up several additional questions, particularly the role these proteins have in organizing and regulating the genome during development and how our findings might impact how we think and investigate laminopathies that do not directly affect lamin C. To fully understand the molecular pathway by which cells re-establish tissue-specific 3D genome architecture after mitosis, it will be important to establish both the role of post-mitotic PTMs of lamin C and the lamin C protein interactome during exit from mitosis.