The AUC-ROC was 0.881 for IFNL3 rs12979860, 0.748 for IFNL3 rs8099917, 0.726 for IFNL3 rs12980275, and 0.869 for IFNL4 rs368234815, suggesting that host genetic factors are generally important for the resolution of viral infection (Fig. 2). This evidence concerns the gene IFNL3 and viral infectious disease.