U3 or U8 (SNORD118) depletion triggers a p53-dependent antitumor surveillance response leading to p53 stabilization, cell cycle arrest, and apoptosis in breast and lung tumour cells and xenograft models [53], while SNORD47 and SNORD76 exhibit a tumour suppressor function in glioblastoma [88]. Here, TP53 is linked to glioblastoma.