In colorectal cancer, ribomethylation levels at 28S-Gm3899(3878) and 28S-Gm4623(4593) are increased via concomitant stabilization of SNORD12C and SNORD78 snoRNP complexes by the SNORD12C host gene encoding the lncRNA ZFAS1. Here, SNORD12C is linked to colorectal cancer.