APOE and atherosclerosis: ApoE-/- mice fed with a high-fat diet (40% fat) show early and extensive atherosclerosis lesions, and various dysregulated miRNAs are reported, such as miRNA-155 [37], miRNA-26a-5p [38], miR-6931-5p, mmu-miR-3547-5p, mmu-miR-5107-5p, mmu-miR-6368, and mmu-miR-7118-5p in aorta atherosclerotic lesions [39].