APOE and hyperlipidemia: In our study, after a 12-week high fat diet, ApoE-/- mice fed with a high-fat diet exhibited a hyperlipidemia profile with increased serum TC, TG, LDL-C, and ox-LDL, and extensive atherosclerotic lesions on the aorta tree compared to the control group, which showed limited lesions in the aortic root and arch region.