Gelseet al.43 found that expression of STC1 and STC2 was significantly higher in damagedtissue when comparing healthy articular cartilage with osteophyte/damaged cartilage.Lambert et al.44 identified STC1 as the most upregulated gene in inflamed synovial tissuecompared with normal/reactive areas and hypothesized that STC1 could be a keymediator of synovium neovascularization in OA synovitis. Here, STC2 is linked to synovitis.