It attracts constantly increasing interest for its activity inseveral biological events related to cellular growth, cancer metastasis,angiogenesis, inflammation, hyperglycemia, atherosclerosis, and, aboveall, coagulation and thrombosis.1 It isnoteworthy that its anticoagulant and antithrombotic activity hasbeen observed also on antithrombin (AT) and heparin cofactor II (HC-II)-freeplasmas. This evidence concerns the gene SERPIND1 and cancer.