In addition, healthy donors with a pre‐existing SARS‐CoV‐2‐specific T‐cell response (as a result of prior infection or perhaps cross‐reactivity) only required one dose of vaccine to induce IFN‐γ and IL‐2 responses with a greater magnitude greater than naïve (no pre‐existing T‐cell response) donors receiving two doses (Figure 3E,F). The gene discussed is IFNG; the disease is infection.