However, accurate clinical staging is hampered by the inability of imaging procedures to detect micro-metastatic seeds [2, 3] and by the non-expression of tumour markers alpha fetoprotein (AFP), beta human chorionic gonadotropin (bHCG) and lactate dehydrogenase (LDH) in almost 50% of the cases [4, 5]. This evidence concerns the gene AFP and neoplasm.