Here, we found that Cdk1-mediated phosphorylation of DAB2IP on Thr531 and Thr546 confers sensitivity to paclitaxel in PCa cells, which suggests that the increased cell killing from taxol-related agents in DAB2IP-abundant PCa cells stems from the cells being trapped in mitosis (Fig. 7). Here, DAB2IP is linked to posterior cortical atrophy.