For example, TRAF7 specifically interacted with MEKK3 and potentiated MEKK3-mediated AP1 and CHOP activation and induced caspase-dependent apoptosis [16], TRAF7 gene mutations drove meningioma tumorigenesis [17], what’s more, TRAF7 promoted ubiquitin-proteasome degradation of P53 in breast cancer [18]. Here, MAP3K3 is linked to breast cancer.