DNMT3A and acute myeloid leukemia: Notably, an aberrant function of the DNA methyltransferase DNMT3A, caused by a recurrent, somatic R882H mutation in hematopoietic stem cells was identified as a key event in the emergence of pre-leukemic hematopoietic stem cells, and the subsequent onset of acute myeloid leukemia (AML) [27].