These findings were corroborated in solid tumors where G9a activity was shown to promote key functional features of CSCs, such as tumor-initiating capacity and epithelium-to-mesenchyme transition (EMT) in human colorectal cancer, non-small cell lung cancer (NSCLC), and head and neck tumor tissues (Fig. 2) [21, 53, 80]. The gene discussed is EHMT2; the disease is colorectal cancer.