Accumulation of ectopic laminins occurs not only in the case of LAMB2-related disease, but also in Alport syndrome (another GBM disease caused by mutations in one of the collagen type IV chains), where deposition of the laminin α2 chain in GBM causes an increased phosphorylation of focal adhesion kinase (FAK).50 The gene discussed is PTK2; the disease is glioblastoma.