CCR6 and systemic sclerosis: According to previous studies, the CCL20/CCR6 axis promotes the chemotaxis of immature dendritic cells, T helper (Th) 17 cells, regulatory T cells, and B cells under both homeostatic and inflammatory conditions [7], contributing to the maintenance of homeostatic immune balance and the development of pathologic inflammation, such as psoriasis [8, 9], atopic dermatitis [9], inflammatory bowel disease [10], systemic lupus erythematosus [11], dermatomyositis/polymyositis [12], and SSc [13].