In the skin of SSc patients, similar expression profiles to those of healthy controls were observed in keratinocytes, dermal small vessels and inflammatory cells, but an increased trend of CCL20 expression was evident in dermal fibroblasts relative to those cells of healthy control skin (the evaluation with grading scale; median [25–75 percentiles], 1.5 [0.25–3.0] versus 0 [0–1.5], p = 0.078). Here, CCL20 is linked to systemic sclerosis.