In cells co-transfected with shSTOML2 and PAI-1 plasmid, the protein expression of GLUT1, HK2 and LDHA was higher than that of cells transfected with shSTOML2 alone but lower than that of PAI-1 plasmid transfected cells (Fig. 5D–G), suggesting that PAI-1 reverses STOML2 silencing-mediated tumor cell growth inhibition in MM. This evidence concerns the gene SERPINE1 and Miyoshi myopathy.