Patients with compensated cirrhosis represented a predominant upregulation of TLR pathway-related genes, including NFKBIA, NFΚB, NFRKB, NFΚBIL1, MAP4K4, TNFRSF1A, IRF1 and ELK1, which were distributed in downstream pathways and target genes (i.e., MAPK8IP3, TIRAP, CD14, TOLLIP and HSPA1A) among adaptors and TLR-interacting protein genes, SIGIRR and TLR9 among TLR genes, and FADD and IRAK1 among the effector genes. The gene discussed is IRAK1; the disease is Cirrhosis.