The latest consensus algorithm for the management of T2D jointly issued by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) [2, 3] recommends GLP-1 receptor agonists (GLP-1RA) as the first injectable therapy, before BI, in most patients with T2D. This evidence concerns the gene GLP1R and type 2 diabetes mellitus.