In this study, we successfully established a rat model of PAH with LIRI and demonstrated that CYP2J2 overexpression and EETs could reduce inflammation, oxidative stress and apoptosis caused by PAH with LIRI, and also reduce pulmonary artery pressure and improve vascular remodeling in rats with PAH with LIRI. Here, CYP2J2 is linked to pulmonary arterial hypertension.