Chen et al. observed that PRDM8 suppresses the occurrence and development of hepatocellular carcinoma pathogenesis by targeting NAP1L1 to suppress phosphatidylinositol 3-hydroxy kinase (PI3K)/protein kinase B (PKB)/mammalian (or mechanistic) target of rapamycin (mTOR) signal. The gene discussed is MTOR; the disease is hepatocellular carcinoma.