An HIF-1 targeted gene, NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4-like 2 (NDUFA4L2), was overexpressed in ccRCC tumor samples and was found to promote proliferation, migration, and drug resistance, based on a combination of untargeted metabolomic and transcriptomic analyses [56]. Here, COXFA4L2 is linked to neoplasm.