Sec61 combined Sec62 and Sec63 serves as core component of the protein translocation machinery in the endoplasmic reticulum (ER) membrane and participates in protein folding, post-translational modification, translocation and unfolded protein response (UPR), especially under conditions of ER stress such as hypoxia and glucose deprivation in the tumor microenvironment [8, 9]. Here, SEC63 is linked to neoplasm.