In consistent with this mechanism, we also observed less infiltration of dendritic cells and CD8+ T cells, as well as low expression of Cxcl10 and Xcr1 (a marker for cross-presenting CD8α + DCs) in Colon 26 tumor tissues (100 mm3) than CT-26.It’s been reported that the lack of effector cells into the TME, as typically observed in tumor with active canonical Wnt signaling, is possibly a main cause of primary resistance to cancer immunotherapies with ICB [34]. The gene discussed is CD8A; the disease is neoplasm.