The tumor-intrinsic immunosuppression usually involves the activation of various oncogenic pathways, including Wnt–β-catenin [14, 15], mitogen-activated protein kinase (MAPK) [16, 17], Janus kinase (JAK)–signal transducer and activator of transcription 3 (STAT3) [18] and nuclear factor-κB (NF-κB) signaling pathways [19]. Here, STAT3 is linked to neoplasm.