REN and Hypertension: Moreover, complex hypertensive milieu (i.e., hypertension, oxidative stress, glomeruli-leaked free fatty acids, and activated renin-angiotensin system) can activate NF-κB signaling, thereby aggravating renal inflammatory actions and accelerates the progression of hypertensive nephropathy (Yan et al. 2018a; Hirohama and Fujita 2019).