APP and Alzheimer disease: Interestingly, this miRNA is upregulated in the cortex of APP/PS1 and APPswe mice, and AD patients [81,82] A miR-206-3p antagomiR injected into cerebral ventricles of APPswe mice or administered intranasally increased BDNF levels, enhanced synaptic density and neurogenesis, and improved memory [82] HDAC2 exerts its regulatory effect on tau via modulation of miR-101b-3p and AMPK.