The comparison of the HAD-depression (HAD-D), HAD-anxiety (HAD-A), mHCL, DAS28-CRP, HAQ, and mood disorders scale scores of the patients who were on sDMARD or on sDMARD in combination with steroid therapy revealed that the patients receiving sDMARD plus steroid therapy had significantly higher scores in all scales. This evidence concerns the gene CRP and depressive disorder.