Although several studies have demonstrated that FOSL2 mediates the progression of colon cancer, hepatocellular carcinoma (HCC), and other malignancies by regulating the epithelial-mesenchymal transitions (EMT), metastasis, and other malignant behaviors (Chen et al. 2020; Li et al. 2018, 2020), little is known about the role of FOSL2 in the occurrence and progression of OC. The gene discussed is FOSL2; the disease is colonic neoplasm.