For instance, alterations in several cellular pathways, including WNT/β‐catenin, mitogen‐activated protein kinases (MAPKs) and protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signalling, have been identified in LMNAH222P/H222P mice, a mouse model of the human LMNA‐associated DCM‐CD.5, 6. Here, AKT1 is linked to Cowden disease.