Since this family displayed the most severe cardiac phenotype, both in terms of cardiac function impairment and in relationship with malignant arrhythmic events occurrence, this further supports the hypothesis that the pro‐inflammatory cytokines we found upregulated in our study, significantly contribute to pathogenesis of the LMNA cardiomyopathy at least in our cohort of LMNA mutant carriers. The gene discussed is LMNA; the disease is cardiomyopathy.