Here, baseline HSV was the only parameter (p=0.045) that significantly predicted IL-6 levels, whereas BMI (p=0.334), ECOG (p=0.448), smoking (p=0.728), T stage (p=0.583), N stage (p=0.880), HPV status (p=0.708), tumor volume (p=0.137), and [18F]FMISO T/M ratio (p=0.651) had no significant impact. Here, IL6 is linked to neoplasm.