Notably, the R273 residue was mutated with similar frequency to an R273C (n = 125/298; 41.9%) or R273H (n = 137/298; 45.9%) across numerous tumor types, but in PCa, selective enrichment of the R273C-p53 was observed (n = 42/66; 63.6%; Fig. 1D, right), suggesting a potential pro-tumorigenic function for R273C-p53 in PCa. Here, TP53 is linked to posterior cortical atrophy.