TP53 and breast carcinoma: Known motif analysis revealed different presumed cofactors for R273C and R273H p53 mutants in both models: R273C-p53 was shown to preferentially associate with p63/p73, while R273H-p53 preferentially associated with multiple transcription factors of ETS family (Supplementary Fig. 4E), which has been observed for R273H-p53 in breast cancer models [49].