As was shown previously in various (non PCa) tumor models, R175H-p53, R248W-p53, and R273H-p53 have been able to partner with YAP, NF-Y, and p73 factors; R248W-p53 mutant also demonstrated strong association with SP1 and ETS2, and R273H-p53 cooperated with CBP, SREBP and NRF2 [45]. Here, SP1 is linked to posterior cortical atrophy.