PI3K-Akt signaling pathway (degree = 29), NF-κB signaling pathway (degree = 11), TNF signaling pathway (degree = 17), Apoptosis (degree = 14), Toll-like receptor signaling pathway (degree = 14) and T cell reporter signaling pathway (degree = 17) might be the key pathways for PRGRC to produce anti-tumor effects. The gene discussed is TNF; the disease is neoplasm.