IFNA1 and infection: Some of these strategies were topical administration of plasmid DNA coding for IFNα1 in the mouse eye to protect against HSV-1 encephalitis59, liposomic intranasal treatment using dsRNA to induce IFN60 as well as recombinant viral vectors such as adenoviruses61 and hepatitis B viruses to express type I IFN to protect against infection and tumor regression61.