Moreover, the IFIT1B (Interferon Induced Protein with Tetratricopeptide Repeats 1B) gene shows the highest fold change among the differentially regulated genes as it was up-regulated in SCD patients in steady-state compared to healthy controls with a fold change of 70.57 (p = 1.7e−9), as well as in SCD patients in VOC compared to healthy controls at a fold change of 313.47 (p = 3.65e−10) (Fig. 2). The gene discussed is IFIT1B; the disease is Schnyder corneal dystrophy.