PELP1 knockdown in medulloblastoma cells results in downregulation of NF-κB, including TRAF1 and IL-8, and expression of ECM-related genes MMP7, MMP9, and MMP1465, the latter of which is upregulated by microglia in late-stage NDD development66. Here, NFKB1 is linked to Neurodevelopmental delay.